It will be only the third time the event has been staged in continental Europe, following Valderrama in Spain in 1997 and Le Golf National in France which gets the event in 2018.
Four nations - Italy, Austria, German, and Spain - had been in the final running after Denmark, Portugal and Turkey withdrew their interest.
“I would like to offer my congratulations to Italy whose bold and ambitious bid has seen them become the host nation for the 2022 Ryder Cup,” said Keith Pelley, chief executive of the European Tour - the managing partner of Ryder Cup Europe.
“History has shown time and again that the Ryder Cup is pure theatre with the players the stars, and there is no question the Eternal City of Rome will provide a wonderful backdrop for one of the great occasions in world golf.
“With Paris in 2018 and now Rome in 2022 being the respective host cities for Europe’s next two stagings of the biennial contest against the US, the magical appeal of The Ryder Cup is set to continue.
“In addition, we have exciting plans for the development of the European Tour and our International Schedule for the benefit of all our players, and Italy shares this ambition. Their commitment to the Italian Open will provide an inspiring benchmark.”
Europe’s Ryder Cup director Richard Hills, a member of the evaluation committee, said it was a tough decision but Rome just edged their rivals.
“The Italian bid was consistently strong and impressive across the board in terms of infrastructure, commercial structure and government support,” he said.
“It was a worthy gold medallist in this particular contest, although there were three impressive silver medallists too in Austria, Germany and Spain, who conducted themselves in a professional manner throughout the process.
“The plans outlined for the golf course at Marco Simone are spectacular alongside the commitment to develop all levels of golf in Italy, and we look forward very much to working with the Italian 2022 Ryder Cup team over the coming years.”
As part of the successful Italian bid there is a significant commitment to the Italian Open by guaranteeing a €6.8m prize fund for the championship for 11 years, beginning in 2017, with next year’s prize fund doubling to a minimum of €2.8m.
Italian two-time Ryder Cup winner Francesco Molinari said that, as well as hosting the European-American clash, would have a major impact on golf in the country.
“It is amazing. It is great news for golf in Italy and golf in general,” he said.
“It is a great chance for Italy but also the Ryder Cup as well to showcase one of the great European cities.
“Golf in Italy has been growing a lot in the last two years and this will have a huge impact and sport in general.
“It has been a tough few years for the country and you can see everyone is excited by the chance to host the Ryder Cup.
“I will be 40 in 2022 so I need to stay in good shape. It would be amazing to play a part as a player, but also amazing to be a part of it in any other capacity.”