The Argentina hitman Aguero has a fine record against the Red Devils, with four goals in his last four games against United, including the winner when the sides met at the Etihad in November.
He says few things can compare to the feeling of scoring at Old Trafford.
“I always love to score, but of course it is even more special to score in the big games,” he told Sky Sports.
“If you score against United at Old Trafford it almost give you shivers, because you can feel the tense atmosphere with most of the stadium being really quiet, but the away end going crazy.”
Manuel Pellegrini’s champions are desperate for points after their shock defeat to Crystal Palace last Monday.
But Aguero believes they can still retain the title. “Of course we can still win it,” he said. “In football, anything can happen... we have seen it so many times before and we’ll see it again. We only focus on ourselves, try to win every game we play and keep pressure on Chelsea.”
Meanwhile Wayne Rooney says he wants to put a smile back on the faces of Manchester United fans with victory in Sunday’s derby.
The 29-year-old is the leading United scorer in derby history with 11 goals, the most famous of which came in 2011 when he scored an acrobatic late winner in a 2-1 victory for United at Old Trafford.
“You play for Man United, you want to win these derby games,” the United captain told MUTV.
“We want to give United fans something to smile about when they go to work on Monday morning, we want them to be the ones to be able to give out the banter to Manchester City fans at work.
“I think it’s a very important game for Manchester United and Manchester City... for the fans and, for me, it’s a massive game of pride.”
For his part, Ashley Young is desperate to avoid being part of the first United team to lose five successive Manchester derbies.
United have more silverware in their trophy cabinet, but last November’s 1-0 victory at the Etihad Stadium was the fourth successive derby win for City. The last time they achieved that feat was 60 years ago.
United have never lost five straight matches to their local rivals and Young wants to end City’s dominance this weekend when the Sky Blues come to Old Trafford.
“That’s something you want to put right,” the United winger said when asked about City’s recent dominanc.
“It will be another massive game.”
Despite City’s recent success in derbies, United go into the match as favourites after registering five straight league wins.
That run has helped United move into third, one point ahead of City, who slipped to their third defeat in five games at Crystal Palace on Monday.
Young thinks United have a good chance of defeating the Premier League champions if they maintain their current form. “We know it will be tough but as long as we can play the way we have shown, especially in the last few games, and add to that, it’s going to be a great game and hopefully we will get the three points.
“We want to keep the momentum going and the positive play.”
Finishing above City would represent a major coup for manager Louis van Gaal, especially after the way his team started the season.
But, wary of the fact that seven matches remain, Young is not letting himself get too carried away despite United’s recent upturn in form.
“It would be nice (to finish above City) but we are just taking each game as it comes,” the 29-year-old said.
“It is obviously going to be another tough one against City next week but we will prepare as well as we can do as we always do.”
Young’s form has been key to United’s recovery. The former Aston Villa midfielder has been so good recently that he has kept record signing Angel di Maria out of the United team.
That has not been enough to get him back into the England squad though.
“There was no conversation (with Roy Hodgson),” said Young, whose last England cap came in September 2013.
“Obviously I will always want to represent my country. I was a little bit disappointed not to be in the squad, but I have just got to make sure I am playing well here at United and hopefully I will get the call at some time soon.”