Russia's UN ambassador has said tensions with the United States are probably the worst since the 1973 Middle East war.

Russia and Syria should face a war crimes investigation for their attacks on Syrian civilians, according to US secretary of state John Kerry.

Talks between the US and Russia have failed to find an agreement to end the violence in Syria

Secretary of State John Kerry is calling on Turkey to provide hard evidence that a US-based cleric was behind a foiled coup attempt last weekend if it wants him extradited.

US Secretary of State John Kerry is to rush to Brussels and London to meet top British and European Union diplomats, as the world grapples with the implications of Britain's historic vote to leave the European Union.

US Secretary of State John Kerry called his visit to a memorial to victims of the 1945 US nuclear attack on Hiroshima “gut-wrenching” and said it was a reminder of the need to pursue a world free of nuclear weapons.

US secretary of state John Kerry has made a brief stop in Afghanistan to promote co-operation from a would-be unity government that has proved largely incapable of running the country less than two years after he worked to install it.

Belgium's Prime Minister has been discussing Tuesday's terror attacks with the U.S. Secretary of State.

The Islamic State (IS) militant group has committed genocide against minority Christians and Yazidis as well as Shi’ite Muslims, US secretary of state John Kerry said, a finding that is unlikely to greatly change US policy toward the group.

US secretary of state John Kerry said yesterday that a “provisional agreement” has been reached on a ceasefire that could begin in the next few days in Syria’s five-year civil war.

US secretary of state John Kerry said a "provisional agreement" has been reached on a ceasefire in Syria's five-year civil war.

Thousands of Syrians are gathering at the border with Turkey after fleeing airstrikes in Aleppo.

The opposing sides will not initially meet face-to-face in planned Syria peace talks in Geneva next week, US secretary of state John Kerry has said.

America and Europe have lifted sanctions against Iran after the United Nations nuclear agency confirmed that the Islamic republic had met all its commitments under a breakthrough deal.

A landmark nuclear deal has moved closer to completion after US Secretary of State John Kerry announced tons of enriched uranium that could potentially be turned to use in atomic weapons were on a ship heading from Iran to Russia.

United Nations Security Council powers have unanimously approved a resolution endorsing a peace process for Syria including a ceasefire and talks between the Damascus government and the opposition – but with no mention of the most contentious issue: the future role of Syrian president Bashar Assad.

US secretary of state John Kerry, in a visit to Moscow yesterday, sought to make progress in narrowing differences with Russian leader Vladimir Putin over how to end the conflict in Syria.

The US and Russia must find common ground to end Syria’s civil war and restore stability in eastern Ukraine, Secretary of State John Kerry said as he met with President Vladimir Putin.

Iran has been invited to participate for the first time in international talks over Syria’s future, US officials said yesterday on condition of anonymity, adding that Iran has yet to reply.

A Palestinian man has been shot dead by Israeli security forces at a checkpoint after he was accused of trying to stab a guard.

US Secretary of State John Kerry said Israel and Jordan have agreed on steps aimed at reducing tensions at a holy site in Jerusalem that have fanned Israeli-Palestinian violence.

US secretary of state John Kerry has expressed a “cautious measure of optimism” after a meeting with Israeli Prime Minister Benjamin Netanyahu about proposals to help defuse the deadly wave of recent violence in Israel.

US Secretary of State John Kerry says he will meet Israeli Prime Minister Benjamin Netanyahu in Germany this week to discuss escalating violence in the region.

The United States is to take in more refugees from around the world to try to help with the on-going refugee crisis.

The US has vowed to help its European allies with the escalating migrant crisis.

The Stars and Stripes were raised over the newly-reopened US Embassy in Cuba for the first time in more than half a century.

US Secretary of State John Kerry has taken the Obama administration’s case for the Iran nuclear deal to wary Arab officials in Qatar.

US secretary of state John Kerry has challenged critics of the nuclear deal with Iran, calling it “fantasy” to think the United States failed to hold out for a better deal at the bargaining table.

US Secretary of State John Kerry is signalling diplomats won’t conclude an Iran nuclear agreement by early on Friday morning, complicating American efforts to quickly implement any deal.

US secretary of state John Kerry has been helicoptered to a Swiss hospital after a bike crash outside Geneva, where he had been holding nuclear talks with Iran’s foreign minister.

A month from a nuclear deal deadline, the top US and Iranian diplomats gathered in Geneva today in an effort to bridge differences over how quickly to ease economic sanctions on Tehran and how significantly the Iranians must open up military facilities to international inspections.

US secretary of state John Kerry has met Russian president Vladimir Putin in a bid to ease badly strained relations over the conflicts in Ukraine and Syria.

US Secretary of State John Kerry is raising objections with Moscow over a plan to sell anti-aircraft missiles to Iran.

Iran nuclear talks have adjourned after an all-night session and will resume in a few hours.

“Substantial progress” has been made toward ensuring that Iran’s nuclear program will not lead to weapons development, US Secretary of State John Kerry said.

The United States will have to negotiate with Syrian president Bashar al-Assad for a political transition in Syria and is exploring ways to pressure him into agreeing to talks, US Secretary of State John Kerry told CBS News in an interview.

Washington and the international community won’t recognise the outcome of tomorrow’s referendum in Crimea on seceding from Ukraine, US secretary of State John Kerry said after six hours of talks with Russia’s foreign minister.

US secretary of state John Kerry yesterday condemned Russia’s “incredible act of aggression” in Ukraine and threatened “very serious repercussions” from the US and other countries, including sanctions to isolate Russia economically.