The On The Road Again tour ends with the third of three nights at Sheffield Arena.
If the reaction in America is anything to go by, the last concert before the boys go on hiatus for at least a year in 2016 will be an emotional affair for fans.
The band used their official Twitter page to ask their 25.5m followers: “Sheffield, are you ready for 1D? #OnTheRoadAgain2015”.
Zayn Malik, Liam Payne, Harry Styles, Louis Tomlinson and Westmeath man Niall Horan were first put together at the boot camp stage of The X Factor in 2010.
Tipped to win at one stage, the much-fancied boyband ended up in third place. Liverpudlian Rebecca Ferguson was runner-up and Matt Cardle was crowned winner.
However, music mogul Simon Cowell believed in the boys and signed them to his Syco record label.
Brit award-winning debut ‘What Makes You Beautiful’ entered the UK singles chart at number one, while 2011 global smash album ‘Up All Night’ sold more than five million copies and reached number one in 17 countries.
‘Up All Night’ went on to top the US Billboard Chart and make pop history as 1D became the first British group to hit number one in the US with their debut album.
Their first four albums have been global smashes. Made In The A.M, album number five, will be released globally on November 13.
However, this year has turned out to be a turning point for both the band as a musical entity and the boys themselves.
The first shock came when Malik quit One Direction in March. The 22-year-old later split from fiancee Perrie Edwards, a member of X Factor winning group Little Mix.
In June, Horan split from Melissa Whitelaw.
A month later, news broke that 23-year-old Tomlinson is to be a father. He is expecting a child with Briana Jungwirth, a stylist.
Payne has also experienced a change in his personal life, splitting with girlfriend Sophia Smith.
Commenting on whether there will be another One Direction, BBC Radio 1 DJ Scott Mills said: “Yes, I think there will be, but I think it could be a very long time.”