Ruan Pienaar will at flyhalf for tomorrow night’s RaboDirect PRO 12 clash against Cardiff Blues at Ravenhill (7.45pm).
Pienaar’s move from nine to 10 sees Paddy Jackson dropping to the bench and Paul Marshall come in to the starting XV at scrum-half.
In total, Ulster Head Coach Anscombe has made five personnel changes and one positional switch to the team that defeated Connacht in their last league outing.
John Afoa, Johann Muller and Iain Henderson all return to the side, while Callum Black is preferred to Tom Court in the front row.
Robbie Diack and Chris Henry both make their 100th appearance for the club and will start alongside each other in the back-row.
Stuart Olding who has scored two tries in his past two games, retains his place at inside centre, with Darren Cave named at 13.
British and Irish Lions winger, Tommy Bowe, is selected on the left wing with Andrew Trimble, who has scored ten tries for the province so far this season, starting on the right.
Sean Doyle is included in an Ulster squad for the first time since breaking his leg in October and will start on the bench.
Nigel Brady is also named among the substitutes in what is likely to be his last game for the club at Ravenhill.
Ulster require three more match points to ensure that they finish at the top of the table.
Anscombe’s team have won their last three RaboDirect PRO12 matches and have lost just once at Ravenhill in the competition all season, going down 12-16 to Ospreys in February.
Ulster (V. Cardiff Blues): J Payne, A Trimble, D Cave, S Olding, T Bowe, R Pienaar, P Marshall; C Black, R Best, J Afoa, J Muller, I Henderson, R Diack, C Henry, N Williams.
Replacements: N Brady, T Court, D Fitzpatrick, D Tuohy, S Doyle, P Jackson, M Allen, P Nelson