After appearing in Cinemax miniseries The Knick, Hewson features in the prestigious list of 10 actors to watch for in 2014, an annual honour list of actors rolled out by the magazine since 1998 which has uncannily predicted the biggest stars of the 21st century.
In recent years, it featured a string of Oscar winners and nominees before they became huge stars, including Lawrence, Nyong’o, Adrien Brody, and Emma Stone.
It also gave the nod to the biggest female star of the year, Fault in Our Stars actress Shailene Woodley, along with Benedict Cumberbatch in its 2011 crop of young thespians on the brink of global stardom.
The youngest daughter of Bono and Ali Hewson, who will next be seen on the big screen in Steven Spielberg’s as-yet untitled Cold War thriller, was the only Irish star named on this year’s list.
Domhnall Gleeson — who is set to appear in Angelina Jolie’s new film Unbroken — was named as one of the actors to watch in 2012.
Hewson is named in the list for 2014 alongside Fifty Shades of Grey star Dakota Johnson and X-Men actress Zoe Kravitz.
The magazine’s 2014 list also features British actor Jack O’Connell who takes the lead role in the hotly anticipated Unbroken, the true story of an American Olympic hero who became a prisoner of war in the Second World War.
Hewson’s first big break came when she was cast in the 2011 indie This Must Be the Place, fittingly playing the daughter of an aging rock star, played by Sean Penn.
But it was her performance in James Gandolfini’s last film, Enough Said, where she played his brooding teenage daughter, that launched her in the movie world.
Bono’s daughter has literally seen her star rise overnight in the US thanks to her starring role in The Knick opposite Clive Owen.
Almost 2m American viewers tuned in to Hewson’s debut as a nurse in the eagerly-awaited series, helmed by Oscar-winning director Steven Soderberg.
The 23-year-old plays a naive nurse from West Virginia named Lucy Elkins assisting a maverick surgeon in the medical series set in the early 20th century.
The series is centred on a pioneering doctor, played by Owen, working in the Knickerbocker Hospital in downtown New York.
The 10-part series, which will be aired on Sky Atlantic in the autumn, follows the ground-breaking surgeons, nurses and staff in Knickerbocker Hospital in 1900 as they push the bounds of medicine in a time of astonishingly high mortality rates and zero antibiotics.