Clooney, who married human rights lawyer Amal Alamuddin on September 27 in Venice, walked on stage during a panel discussion for the upcoming Disney fantasy film Tomorrowland, in which he plays a hermit inventor.
“It’s not lost on me that I’m spending my honeymoon at Comic-Con,” Clooney told the crowd to thunderous applause.
Panel moderator Chris Hardwick then asked the actor: “So what did you say, ‘Honey we’re going to Comic-Con’?”
“She was as confused as you all were,” Clooney said.
Before walking on stage, Disney showed the crowd a two-minute trailer of the film.
“We’ve been waiting on this for a year and a half and that’s it,” Clooney told director Brad Bird. “I’m barely in the teaser.”
Later Clooney introduced an exclusive clip that prominently showed him and Britt Robertson in an action sequence, calling the experience larger than anything he had ever done.
“We were all over the world for this film. Hugh (Laurie) and I got to get in trouble in the Bahamas. That was fun, two former television doctors,” Clooney told the crowd to prolonged laughter.
“Bring on that McSteamy guy, we’ll take on all of them TV doctors.”
Laurie starred in House, while Clooney appeared on ER.
He also hammed it up with references to superheroes. “Since I did Batman, I’ve been de-invited from Comic-Con. I met Adam West and apologised.”
Tomorrowland will be released in May.
Laurie joked about his castmate Clooney before his surprise appearance.
“I’m glad he’s actually not present at the moment because it frees me up to say one or two things about George Clooney, who has constructed, painstakingly, this image of the good guy, the nice guy, everyone’s friend, a chivalrous saint. Well, there’s been no mention of the drinking.
“There has been no mention of the shouting; the ceaseless shouting! Lying about his age. He’s 75, if he’s a day.”