Winehouse, currently undergoing a stint in rehab, has been nominated for villain of the year alongside Prime Minister Gordon Brown, his predecessor Tony Blair and US President George W Bush.
She will also battle Pete Doherty for the worst dressed title.
There is some good news, however, in the form of nominations for best solo artist and best music DVD.
Arctic Monkeys have a record seven nominations in the awards. They are up for best British band, best live band, best album and album artwork for Favourite Worst Nightmare, Best track for Fluorescent Adolescent and best video for Teddy Picker, while frontman Alex Turner is a best dressed contender.
Since bursting onto the music scene, the Sheffield band have notched up 15 NME award nominations — making them the magazine’s most voted band of the decade.
The other nominees for best British band are Babyshambles, the Cribs, Klaxons and Muse.
Babyshambles are also contenders for best album with Shotters Nation and best music DVD for Up The Shambles. Their frontman Doherty is nominated for best dressed and worst dressed.
The worst album award will go to either James Blunt, the Hoosiers, Mika, Britney Spears or Leona Lewis.
The winners will be announced at a London ceremony on February 28, to be broadcast on E4.