Excess weight alone can lead to heart disease

MIDDLE-AGED people who are overweight but have normal blood pressure and cholesterol levels are kidding themselves if they think their health is just fine, scientists have warned.

Northwestern University researchers tracked 17,643 patients for three decades and found that being overweight in mid-life substantially increased the risk of dying of heart disease later in life - even in people who began the study with healthy blood pressure and cholesterol levels.

High blood pressure and cholesterol are strong risk factors for heart disease.

Both are common in people who are too fat, and often are thought to explain why overweight people are more prone to heart disease.

But there is a growing body of science suggesting that excess weight alone is an independent risk factor for heart attacks, strokes and diabetes.

“The take-home message would be pay more attention to your weight even if you don’t have an unhealthy risk factor profile yet,” said lead author Lijing Yan, a researcher at Northwestern and Peking University.

The study appears in yesterday’s Journal of the American Medical Association.

Participants were men and women in their mid-40s on average who had no heart disease or diabetes when the study began. They were followed for an average of 32 years. The researchers tracked deaths from cardiovascular disease and diabetes, and hospitalisations for those conditions, starting at age 65.

A total of 1,594 heart disease deaths occurred, 31 of them in people who started the study with normal blood pressure and cholesterol.

Among participants with normal blood pressure and cholesterol at the start, those who were obese - or grossly overweight - were 43% more likely than normal-weight participants to die of heart disease later on. They were also four times as likely to be hospitalised for heart disease.

Participants who were modestly overweight but had normal blood pressure and cholesterol still ran a higher risk than the normal-weight people.

A total of 1,187 participants - 494 of them overweight or obese - had normal blood pressure (120 over 80 or lower) and cholesterol levels (under 200) at the outset.

Standard body-mass index categories were used to define weight - BMIs of 25 to 29 were considered overweight and 30 and above was obese.

Ms Yan said it was possible that some overweight participants developed high blood pressure and cholesterol problems during the study, which could have contributed to their deaths. But she said researchers increasingly believe that being too fat causes other cardiovascular problems, too.

Dr JoAnn Manson, chief of preventive medicine at Harvard’s Brigham and Women’s Hospital said there was still a common misconception that excess weight is nothing to worry about until high blood pressure and cholesterol develop.

“Patients say that all the time, and many doctors actually will say that to patients too.”