Fresh from winning a Super Rugby title with the Hurricanes, Gibson-Park is given his first taste of Leinster action with New Zealand-born Joey Carbery outside him at 10.
Rob Kearney will also be back in the thick of the action following his recovery from a hamstring issue that forced him to miss the Irish tour to South Africa.
Kearney will be joined by Garry Ringrose and Adam Byrne in the back three, Ringrose moving from centre to the right wing position.
Noel Reid also makes his first start of the pre-season at number 12 with Rory O’Loughlin — a try scorer against Ulster and Gloucester — beside him at 13.
In the pack, there are a number of changes from last weekend against Gloucester with Cian Healy making a first start for Leinster since April having recovered from neck and knee injuries. Beside him, James Tracy and Michael Bent complete the front row.
Ross Molony will captain the side from the second row with the returning Mike McCarthy alongside him. McCarthy last played in the Six Nations in February against France.
Former Munster player Ian Nagle has been included in an extended substitutes list of 16 players, most of whom are likely to see game time.
R Kearney, G Ringrose, R O’Loughlin, N Reid, A Byrne, J Carbery, J Gibson Park, C Healy, J Tracy, M Bent, R Molony (captain), M McCarthy, J Murphy, D Leavy, P Timmons.
B Byrne, A Porter, J Loughman, H Triggs, D Ryan, N McCarthy, C Marsh, Z Kirchner, S McNulty, P Dooley, I Nagle, J van der Flier, C Rock, R Byrne, T Daly, B Daly.