O'Meara has recovered from a leg injury but his place is taken at scrum half by Brian O'Riordan.
The return of Felipe Contepomi may have had something to do with the dropping of O'Meara and the Argentinean is now likely to be slotted in as Leinster's main goal-kicker as well as carrying out his primary duties at out half.
Leinster still have an outside chance of capturing the league title but they are fast running out of time.
They currently lie in seventh position but are 14 points adrift of leaders Ulster. However, with Munster in fourth place and the Warriors in fifth just a point behind, the Irish side could do their old rivals a favour. A Leinster win would do immense damage to the prospects of the Warriors going all the way.
Leaders Ulster are away to Glasgow but seem certain to pick up a win.
Anthony Horgan returns to the Munster side for a crucial match against Llanelli at Stradey Park this evening. He replaces Mossie Lawlor, who retains his place.
Captain Jim Williams leads the side from the number six position and up and coming star, Stephen Keogh is named at number eight alongside Williams and Eddie Halvey.
J. Norton, J. McWeeney, G. Brown, C. Warner, B. Burke, F. Contepomi, B. O'Riordan, S. Brophy, G. Hickie, P. Coyle, A. Kearney, B. Gissing, N. Breslin, D. Dillon, S. Jennings.
Replacements: E. Bohan, D. Blaney, S. Crawford, C. Potts, B. O'Meara, M. Leek, J. Downey.
S. Payne, J. Kelly, J. Jones-Hughes, R. Henderson, A. Horgan, J. Holland, E. Reddan, S. Kerr, J. Blaney, G. McIlwham, T. Hogan, D. Pusey, D.J. Williams (Capt.), S. Keogh, E. Halvey.
Replacements: M. Lawlor, C. O'Sullivan, F. Murphy, F. Roche, J. Flannery, D. Sheehan, P. Malone.