Stablemate Await The Dawn is also in the race as a second option but the four-year-old’s first preference is the Breeders’ Cup Turf.
So You Think touched down on European soil having carried all before him in Australia, but while he has since won four times, including three Group Ones, the giant colt has also suffered three defeats.
He is set to take to the dirt surface for the first time at Churchill Downs.
Aidan O’Brien has also entered Uncle Mo, Gio Ponti and Havre De Grace are three of the better-fancied entries for the home team.
Joining Await The Dawn in the Breeders’ Cup Turf could be stable companion St Nicholas Abbey and Sir Michael Stoute’s beaten St Leger favourite Sea Moon.
Top-class fillies Midday and Sarafina interestingly have the race as their first preference, with the Filly & Mare Turf, which the former won two years ago and was second 12 months later, second choice.
David Lanigan has entered Meeznah, but she is seemingly bound for the Breeders’ Cup Marathon, for which Ballydoyle’s Harrison’s Cove and the Andre Fabre-trained Brigantin also hold an entry.
There are plenty of other likely European challengers in Friday’s Filly & Mare Turf, including Fabre’s Announce, Roger Varian’s Nahrain and O’Brien’s Misty For Me.
Goldikova will bring the house down if she can secure the Breeders’ Cup Mile title for a remarkable fourth successive year.
She will face a strong challenge from the Richard Hannon-trained Strong Suit, with Andre Fabre’s Byword and Ballydoyle’s Zoffany also booked for the trans-Atlantic jaunt.
O’Brien has Crusade and Daddy Long Legs engaged in the Breeders’ Cup Juvenile, with the latter in the Juvenile Turf as a second preference.
Also in the Juvenile Turf for the Europeans are Alan McCabe’s Caspar Netscher, Varian’s Farraaj and the O’Brien-trained pair of Learn and Wrote.
Caspar Netscher has the Juvenile Sprint as his second preference. Brian Meehan’s Shumoos is the only other British possible.
Gerard Butler has Pachattack entered the Ladies’ Classic, and has been based at the trainer’s American yard for much of this season.
John Gosden’s Questing and Ballydoyle’s Homecoming Queen are the two representatives in the Breeders’ Cup Juvenile Fillies, with both having the second preference of running in the Juvenile Fillies Turf.
Either way, Gosden is set to be represented in the latter race with the exciting Elusive Kate among the entries.