There was no middleweight world title on offer for the Englishman but his slick points win means he can consider himself a strong contender to face unbeaten American Floyd Mayweather in 2015.
Khan has long sought the fight but now, after impressing in Vegas, can offer a genuine case for the match being made.
If he cannot meet Mayweather, he is eyeing former stablemate Manny Pacquiao.
Either of those would mean there will be no domestic grudge match with IBF champion Kell Brook next, but Khan wants to cash in while his stock is high.
“If Mayweather doesn’t happen, Manny Pacquiao is a great name,” he said.
“We trained together, there’s a great storyline there. With Kell Brook, that fight will always be there but at the moment I want to catch the right guys because they’re at the top of their game.”
Khan is targeting a May 2 date with Mayweather, who has not lost in 47 fights.