An estimated 2.5 million American troops and their weapons have passed through Shannon since the US established the airport as a military hub 13 years ago.
Today, peace activists will gather at the airport to mark the anniversary and call on the Government to stop colluding with US army campaigns.
Among those taking part will be Margaretta D'Arcy, who was imprisoned twice this year for opposing US military stopovers in Shannon.
"Millions of tonnes of weaponry have travelled via Shannon - including weaponry that has been used against the Palestinians by the Israelis," said Niall Farrell, from the Galway Alliance Against War.
"We, the Irish people, have blood on our hands. And it's about time we woke up to realise that."
A delegation from the Oireachtas Petitions committee visited the area at the beginning of the month as part of a review of the situation. The committee will make recommendations to the Government based on its discussions with the airport authority, gardaí and campaigners.