Extra trains and cross river ferries are being laid on and gardaí will be enforcing parking restrictions in certain areas of the town.
Iarnród Éireann will be running additional services on the Cork to Cobh line, providing a service every 30 minutes from 6.30am until 7.30pm.
Cobh can also be accessed from stations at Midleton, Carrigtwohill, Little Island and Glounthaune, where free parking is available.
For train timetables and for further information see irishrail.ie
The cross-river ferry between Glenbrook and Carrrigaloe will run two vessels for those travelling from the west side of the harbour.
Road closures will be in effect in Casement Square and on part of Westbourne Place from 11.30am until 10.30pm.
One-way systems will operate going into Cobh along the High Road and out of the town along the Lower Road, while disabled parking spaces will be set up outside the Sirius Arts Centre on Lower Road.
The event organisers are also marking parking spaces available at Verolme Dockyard, adjacent to Rushbrooke railway station; at Cobh Pirates Rugby Club and the St Colman’s Cathedral carpark.
Supt John Quilter said that additional gardaí would be drafted in for the day and would be aided by event stewards.
“I would encourage all those travelling to Cobh to plan their travel in advance and to check for updates in relation to parking and traffic restrictions,” he said.
For more details and updates on road closures and traffic restrictions see www.portofcork.ie
Port of Cork commercial manager, Captain Michael McCarthy, who is lead organiser of the event, said: “We expect that up to 10,000 people from across Ireland and beyond, many of whom have personal connections to the Lusitania disaster, will descend on the town of Cobh to remember all those who lost their lives on May 7, 1915.”