The parents of Nóra Quoirin will be two of the guests on Friday's Late Late Show.
Meabh and Sebastian will join Ryan to thank the Irish public for their continued support following the Nóra's death.
The teenager was found dead after 10 days missing in the Malaysian jungle while on a family holiday.
Nóra's parents vowed last week
It had been ruled that an inquest would not be held.
Following the news that Malaysian authorities have decided to close the case into the death of the 15-year-old, Meabh and Sebastian will explain why they are now looking for the assistance of the Irish public.
Former Ireland midfielder David Meyler will also be on the show.
The ex-Hull City star will be discussing how he has swapped his football boots for virtual ones.
Meyler is making waves as one of the best FIFA videogame players in the world and will be joining Ryan for a chat.
Billionaire businessman Alan Sugar will also be on the couch with Ryan.
He will be talking about the "calibre of aspiring Irish entrepreneurs he's on the lookout for ahead of the next series of The Apprentice."
A former member of The Beatle will also be in the RTÉ studio.
Pete Best, the band's former drummer, will be in studio to discuss his early days as part of the group that went on to be the biggest band in the world.
He will also discuss his subsequent career as a musician, having made way for Ringo Starr in 1962.
The show will also speak with people who have benefited from organ donation.
Limerick's Hermitage Green will also be among the musical performances tomorrow evening.