Anne Robinson is to present Have I Got New For You next week.
A BBC spokeswoman says the host of the quiz show The Weakest Link will make a one-off appearance next Friday.
The audience of the BBC1 satirical quiz show had a taste of the programme without Angus Deayton, its host of 12 years, at its recording on Thursday.
Deayton, 45, was forced to step down as host of Have I Got News For You on Tuesday after claims about his sex life and alleged use of drugs made his position "untenable".
In the show, to be broadcast on Friday, his one-time colleagues did not miss the opportunity to have a laugh at his expense.
Panellist Paul Merton stood in as host and started by saying there had been a mistake at the ending of last week's show.
He then showed a clip of Deayton bringing the programme to a close, but with the addition of the EastEnders dramatic drum finale music played over the top.
Regular panellist Ian Hislop, comedians Ross Noble and Rich Hall and journalist Andrew Neil also joined in with jibes at Deayton.
They were shown clips of Winona Ryder's shoplifting trial and Merton went on to allude to Deayton's own attempts to gloss over the newspaper headlines about him.
"She went on to a TV comedy programme to try to laugh it off. It never fails," he said.