Sister Clare Theresa Crockett, 33, died when a stairwell collapsed in the school where she was working in Playa Prieta earlier this month.
Hundreds packed into St Columba’s Church close to her family home in the Brandywell area of Derry for Requiem Mass.
Fr Eamon Graham, who led the service, said: “She was a striking example of Derry womanhood. Clare asked herself what she could do to make the world a better place and how she could serve God and help the most vulnerable.
“And to do that she went to the end of the earth and she took her goodness with her.”
More than 480 people were killed and 4,000 others injured in the powerful quake, which had a magnitude of 7.8 — the strongest to hit the country since 1979.
Sister Clare, a nun in the Home of the Mother order, had been teaching children in a rural part of the country, including guitar lessons.
She died alongside a number of local girls in the school.
Fr Graham told the congregation that many who met the self-confessed former party girl and budding actress had been inspired to change direction.
He added: “She continued to do this in her death. She enjoyed life and she loved life. She always said she wanted to be famous — but she gave all that up. But in a way she has achieved fame and that will help her good work continue.”
As her coffin, adorned with floral bouquets, was carried into the church, a guard of honour was provided by girls from St Cecilia’s College where Sister Clare had received their first-ever award for kindness.