The Wimbledon champion bought Cromlix, 5km from his home town of Dunblane in central Scotland, in February last year.
The Victorian mansion was extensively refurbished and reopened at the beginning of this month and includes its own private chapel and loch.
Cromlix took the top prize at the Scottish Hotel Awards during a ceremony in Edinburgh on Sunday night, with judges calling it a “national treasure”.
Awards chairman Gary McLean-Quin said: “This superbly balanced combination of solid investment, vision and hugely experienced management has made Cromlix the unanimous choice of judges this year.
“Hotels often have sizeable sums of money spent on them but that’s only half the battle.
“What impressed us — and specifically enabled this award — was the involvement of award-winning management and individuals in every department — people of excellence we have known for a decade. The result is no less than a national treasure. We must also pay tribute to Andy’s mother Judy who has undoubtedly played a great part in this transformation.”
The accommodation at Cromlix features 10 bedrooms and five suites which overlook manicured grounds and tennis courts.
The hotel is being managed by Inverlochy Castle Management International and is already fully booked for the Ryder Cup, which is being staged at the nearby Gleneagles later this year.
Murray, 26, made a visit to the venue last week as he returned to Scotland for a series of events which saw him granted the freedom of Stirling and be awarded with an honorary doctorate from the city’s university.
Speaking at the time, he said: “I just got here last night and it’s the first time I’ve seen it since it’s all been done and it looks great.”