Teen develops early test for pancreatic cancer

Jack Andraka has in a short space of time gone from being a typical teenager unaware of the pancreas to one with a cheap way to detect cancer in the organ before it turns deadly.

“Through the internet, anything is possible,” said Andraka while telling the story of his screening breakthrough at a prestigious TED Conference (Technology, Entertainment, Design) in California this week.

“If a 15-year-old who didn’t know what a pancreas was could figure out a way to detect pancreatic cancer, imagine what you could do.”

Andraka, who turned 16 in January, recounted how he began scouring the internet three years ago for information about pancreatic cancer after it killed a cherished family friend.

He told of being shocked to learn that the cancer was typically found too late to save people. On top of that, the test used to screen for the illness was 60 years old, he said.

“That is older than my dad,” he quipped. “More important, it is expensive, inaccurate, and your doctor would have to be ridiculously suspicious that you had the cancer to give you this test.”

He reasoned that what was needed was a test that was inexpensive, fast, simple, and sensitive.

“Undeterred due to my teenage optimism, I went online to a teenager’s two best friends: Google and Wikipedia,” said Andraka.

What he found was there were thousands of proteins that could be detected in the blood of people with pancreatic cancer, and he hunted for one that could serve as an early flag for the illness.

“Finally, on the 4,000th try when I am losing my sanity, I found the protein.”

The revelation came in what he described as an unlikely place, a school biology class.

“I was sneakily reading this nanotubes article under my desk while we were supposed to be paying attention to antibodies.

“Suddenly it hit me that I could combine what I was reading with what I was supposed to be thinking about.”

He described a recipe for making paper sensors to detect the protein — mesothelin — in blood.

The test costs three cents, takes minutes, and appears to be 100% accurate, according to his TED talk.

Andraka said he sent out 200 requests to scientists for lab space to continue his work, only to be rejected by all but Johns Hopkins University, where he was fiercely grilled before being taken in.

He commenced to fix holes he discovered in his “once brilliant procedure” and went on to be awarded the 2012 Intel Internat-ional Science and Engineering Fair grand prize.

Andraka described his approach as having the potential to be tailored to screen for other forms of cancer as well as heart disease or HIV/AIds.

He told of currently working on “something the size of a cube of sugar” that could “look through your skin” and study blood or signs of almost any disease. The cost? An estimated $5 (€3.8).