Alvaro Morata and Michy Batshuayi proved there is life after Diego Costa as Chelsea fought back to win 2-1 at Atletico Madrid.
Costa, whose return to Atletico was completed on Tuesday, watched on as Chelsea responded from David Luiz's needless concession of a penalty scored by Antoine Griezmann.
Former Real Madrid striker Morata headed in Eden Hazard's cross for his seventh goal in eight games for Chelsea, before Batshuayi struck with the final kick of the game.
The dramatic finish gave the Blues two wins from two Champions League Group C games.
It was no less than Antonio Conte's visitors deserved after a strong showing, with Tiemoue Bakayoko, N'Golo Kante, Morata and Hazard particularly impressive.
Chelsea beat Qarabag 6-0 in the opening round and next play Roma in a double-header.
This was the trickiest of Chelsea's group games as Atletico played in Europe at their new Estadio Wanda Metropolitano home for the first time.
And Los Rojiblancos, who had won 30 of their last 36 European games at the Vicente Calderon stadium, losing just twice, suffered their first home defeat to English opposition.
Only one former Chelsea player was in Atletico's starting line-up, Filipe Luis, with Fernando Torres on the substitutes' bench.
Costa, who scored twice in 15 Champions League games for Chelsea, watched from the stands after returning "home".
Diego Costa looks he just dropped the dopest R&B album of 1996 pic.twitter.com/qaiV4CzhId— Mike Ryan (Ruiz) (@MichaelRyanRuiz) September 27, 2017
Chelsea goalkeeper Thibaut Courtois spent three years on loan at Atletico, winning LaLiga in 2014 and reaching the Champions League final at parent club Chelsea's expense.
Courtois' Belgian compatriot Hazard attempted to ignite Chelsea's attack, taking heed of head coach Antonio Conte's pre-match encouragement to take his game to the next level.
The playmaker first ran at Atletico and found Morata, who dragged a shot wide across goal.
Hazard fired into the side-netting before flicking on for Morata to again shoot wide.
Hazard next fired a 25-yard drive which was deflected on to the post.
Morata went close from Luiz's cross, but his header was straight at Jan Oblak. Either side and it would have been 1-0 to Chelsea.
A combination of Luiz and Gary Cahill cleared Juanfran's cross towards Griezmann, who had hardly had a kick until presented with a spot-kick by Luiz.
Yannick Carrasco's shot was blocked for a corner from which Luiz, using his left arm which was strapped to protect his fractured wrist, hauled over Hernandez.
Luiz was playing in the midst of a three-match domestic ban for his dismissal against Arsenal which will see him miss Saturday's match with Manchester City.
This was another costly error which saw him booked. Griezmann converted the penalty.
It should have been 2-0 at the interval. Courtois parried Koke's shot straight to Angel Correa, who side-footed wide.
Chelsea equalised after 60 minutes when Hazard crossed right-footed from the left and Morata netted with a precise glancing header.
It was his first goal in seven games against Atletico as he became the first opposition player to score at their new home.
Chelsea soon came close to a second. Fabregas prodded a Hazard cross wide when stretching to meet the ball before Kante shot wide.
Morata spurned a difficult one-on-one chance as Oblak forced him wide.
But Chelsea's persistence paid off when Batshuayi, on for Morata, tucked in Marcos Alonso's cross.