Liverpool forward Iago Aspas earned a recall to the starting line up for the visit of Southampton as replacement for injured playmaker Philippe Coutinho.
Manager Brendan Rodgers made two other changes from Monday’s 2-2 draw at Swansea, bringing in the fit-again Daniel Agger and restoring Kolo Toure as he named four centre-backs in his defence.
Southampton named the same side which drew 0-0 with West Ham last weekend.
Liverpool: Mignolet, Toure, Skrtel, Agger, Sakho, Gerrard, Lucas, Henderson, Aspas, Moses, Sturridge.
Subs: Brad Jones, Jose Enrique, Alberto, Sterling, Ibe, Kelly, Wisdom.
Southampton: Boruc, Clyne, Fonte, Lovren, Shaw, Wanyama, Schneiderlin, Lallana, Osvaldo, Rodriguez, Lambert.
Subs: Kelvin Davis, Steven Davis, Ramirez, Ward-Prowse, Cork, Chambers, Hooiveld.
Referee: Neil Swarbrick (Lancashire)