Fiorentina romped to their first UEFA Cup triumph of the Group C campaign with a crushing 6-1 success at home to Elfsborg to go top of the table.
Martin Jorgensen fired La Viola into the lead on just three minutes, and Christian Vieri doubled their advantage a minute later.
Stefan Ishizaki scored just before the break to give the visitors a fighting chance.
But two goals in three second-half minutes from Marco Donadel and Per Kroldrup killed off the game – before Jorgensen and Samuele Di Carmine completed Elfsborg’s humiliation.
In the same group, attacking midfielder Matias Fernandez produced an inspired performance to help Villarreal register their first win, 2-1 away to Mlada Boleslav.
The Chile international had a hand in setting up goals for forward Kahveci Nihat and midfielder Gonzalez Santi at the Cazorla Mestsky Stadion.
A late strike from Mlada Boleslav midfielder Noel Alexandre Mendy ensured a tense finish – but Manuel Pellegrini’s side held on to claim the points.
Larissa lost their unbeaten home record in Europe as Fatih Tekke’s late goal gave Zenit St Petersburg a thrilling 3-2 win in Group A.
With just 13 minutes remaining Tekke got on the end of fellow substitute Alejandro Dominguez’s cross.
Zenit had gone ahead at the end of the first half through Pavel Pogrebniak; Larissa hit back through Nektarios Alexandrou and Giorgos Fotakis, before Konstatin Zurianov drew Zenit level.
Panathinaikos maintained their 100% record in UEFA Cup Group B, by edging out FC Copenhagen 1-0 at Parken.
Dame Ndoye scored the only goal, while substitute Hjalte Bo Norregaard missed a penalty and hit the woodwork for the home side – playing their first match in the group stage.
Dinamo Zagreb’s opening game in Group D ended in frustration as they were held to a goalless draw by FC Basle.
Bruno Cheyrou slotted a late penalty to rescue Rennes a deserved point from their clash at home to SK Brann.
Azar Karadas’ first-half header and a backs-to-the-wall defensive effort looked as if they were going to earn the visitors a hard-fought three points.
But captain Cheyrou scored from the spot, after Jires Kembo-Ekoko was tripped three minutes from time.
Spartak Moscow opened their Group E campaign with a hard-fought 2-1 home win against Bayer Leverkusen.
Roman Pavluchenko converted a penalty, and Mozart also celebrated his 28th birthday with a goal from the spot.
Substitute Paul Freier pulled one back for the German side.
Karol Kisel scored two minutes from time to give Sparta Prague a 3-2 victory at Toulouse.
Johan Elmander put the home side ahead in the first half, before Kisel and Libor Dosek replied within a minute of each other.
Fode Mansare levelled matters for Toulouse, but Kisel then settled the match.
Mattias Lindstrom grabbed an equaliser five minutes from time as AaB snatched a point against Anderlecht in Group G, after Marcin Wasilewski had put the Belgian side ahead.
Helsingborg claimed a surprise 3-2 victory over Galatasaray in Group H at the Ali Sami Yen Stadium.
The Swedish side took a two-goal lead thanks to Henrik Larsson and Razak Omotoyossi, but the home side pulled a goal back just before half-time through Shabani Nonda.
Defender Christoffer Andersson then put the visitors further ahead with a fine individual strike, before Nonda struck late on to ensure a nervy final few minutes.
Bordeaux have one foot in the knockout stages of the UEFA Cup after coming from behind to win 2-1 at Austria Vienna.
Brazilian midfielder Wendell coolly slotted a penalty home in the 88th minute, after Marouane Chamakh had cancelled out Sanel Kuljic’s early opener for the hosts.