Having had treatment on the pitch, he appeared to walk it off and came back into the match, but moments later the five-goal striker was back down, his leg having buckled as he ran, and he subsequently departed once again on a stretcher.
Howe — who has already lost Tyrone Mings and Max Gradel to serious knee injuries this season — said: “It doesn’t look good.
“He is in a brace and on crutches and is in a bit of pain — there is a bit of swelling. We won’t know until we get it scanned and properly looked at, but it is worrying for us.”
Asked about the decision that saw Wilson briefly back on the field, Howe said: “I think Callum felt his knee was okay, and you are in the hands of the player — he wanted to carry on, such is his nature. Obviously that wasn’t the case, and it was a real key moment.”
With Bournemouth still looking a little shell-shocked, they fell behind in the 32nd minute via Ireland’s Jonathan Walters’ close-range finish.
They hit back after the break through Dan Gosling’s 76th-minute equaliser, before Stoke substitute Mame Biram Diouf headed in the winner with seven minutes to go.
The result was Stoke’s first Premier League win this season and saw them exit the relegation zone. Potters boss Mark Hughes said: “It was an important win. I’d argue we have probably played better in other games and got beaten. But today was about getting three points.” Hughes saw with winger Xherdan Shaqiri forced off after picking up an apparent hamstring problem before the interval. Hughes said: “We’ll settle him down tomorrow, probably get a scan on Monday and see what the damage is.”
Butland, Johnson, Cameron, Wollscheid, Pieters, Whelan, Adam (Van Ginkel 75), Shaqiri (Afellay 54), Krkic (Diouf 62), Arnautovic, Walters
Boruc, Francis, Cook, Distin, Daniels, Ritchie, Surman, Gosling, Pugh (Smith 87), Tomlin (King 71), Wilson (Murray 17)