It's a game that could cement the Londoners title credentials but with Jose Mourinho looking to gain a bit of momentum as Manchester United coach, it's the most intriguing game between the two English football giants in years.
Ryan Giggs (1999)
Probably one of the Welsh man's greatest goals in a Man United shirt, although there are many to choose from.
110 minutes gone on the clock, Giggs picks off a pass in his own half and sets off. The rest, as they say, is history.
Thierry Henry (2000)
Arsenal were beginning to find real form in 2000, and Thierry Henry was beginning to show he was a superstar. This goal against an unsuspecting Fabien Barthez is one all Arsenal fans will watch time and time again.
With the balled played into his feet, Henry chipped it up for himself, turned and fired. It looks so effortless but the truth is it's anything but.
Freddie Ljungberg (2001)
Another man from the beginning or Arsenal's golden age in modern football, Freddie Ljungberg would become a key cog in the Invincable's team, much like Henry.
Arsenal easily won the ball back deep in the Man United half and Robert Piers fed Ljungberg who delivered a superb chip over Barthez. A fine goal which sparked Arsenal to come back from a goal down to win 3-1.
Cristiano Ronaldo (2009)
The 2009 Champions League semi-final second leg was finely poised with Man United travelling to the Emirates Stadium holding a slender 1-0 lead.
Arsenal were hopeful of turning over their rivals at home, but Cristiano Ronaldo had other ideas. The winger scored two stunning goals and opinion has been divided in the Exam Viral team over which is better.
The first was an audacious free kick from 40 yards out.
The second was a wonderful team goal showing counter attacking football at it's best.
We'll let you decide which is better.
Ashley Young (2011)
Wouldn't you 8-2 be an Arseanl fan, or so the joke went. One of Ferguson's greatest days against Arsenal and surely Wenger's worst.
Welbeck opened the scoring, Rooney scored a hat trick which included two superb free kicks, Nani scored with a delicate lob and Young netted twice but it was his first that we're picking out today.
Poor Arsenal defence meant Young recieved the ball 20 yards out and he curled it inch perfectly into the top corner. Like him or loathe him, it's a special goal.
How could we compile a list of great goals between Arseanl and Man United without mentioning one truely incredible goal. Step up John O' Shea.
How he managed to ghost into the Arsenal box unmarked is anyones guess. And heaven knows how he managed to produce such a superb goal.
His face seems to suggest he hasn't a clue either.
Let's hope for a few similar ones tonight.