United are reportedly looking to strengthen their backline in the winter transfer market after losing defenders Rafael, Phil Jones, Jonny Evans, Luke Shaw and Marcos Rojo to injuries.
Godin has been strongly linked with a move to Old Trafford, with United manager Louis van Gaal reportedly keen to acquire the Uruguay international’s services.
But when asked whether Atletico would accept an offer in the region of 20million euros from United for Godin, Simeone told the Spanish media: “Let’s talk about something else.
“How much? Twenty? For Godin?
“It must be a mistake.”
Godin, who helped Uruguay reach the last 16 of the World Cup in Brazil, is under contract with the Spanish champions until June 2018, having moved from Villarreal ion 2010.