It will mark the first time the Wanderers midfielder has attended a game since he suffered a cardiac arrest in an FA Cup tie between the sides at White Hart Lane on March 17.
Bolton manager Owen Coyle said: “We are absolutely delighted that we will be able to welcome Fabrice and his family back to the Reebok, and we are all looking forward to seeing him.
“It’s fitting that the match is between these two clubs and that Fabrice is able to come along.
“I know Fabrice is very keen to show his appreciation to both sets of fans for their support.”
The return of the midfielder will be a welcome boost to Coyle, who also feels his recent encounters with Tottenham in the north-west show why his team should go into the clash with the Londoners at the Reebok Stadium full of confidence.
Although Wanderers have been beaten five times at White Hart Lane in all competitions since Coyle was appointed as their manager in January 2010, at home they have held Spurs to a 1-1 draw in the FA Cup and pulled off an impressive 4-2 league win over them.
Those experiences have given Coyle plenty of encouragement that his relegation-haunted side can pick up a valuable three points tonight.
“I think Spurs are a different proposition away from home than they are at White Hart Lane,” Coyle said.
“I have had two encounters with Spurs at the Reebok Stadium — a fifth-round FA Cup tie which we drew and should have won, and then when we beat them last season in the Premier League.
“Tottenham at White Hart Lane are absolutely formidable, but at the Reebok we believe we have a real opportunity to win the game.”
Bolton are currently 18th in the table, separated from 17th-placed QPR by goal difference alone.
Spurs boss Harry Redknapp, meanwhile, believes results are so erratic at this stage of the season that he cannot be sure whether his side will miss out on fourth place or snatch third.
With the FA opting to employ Roy Hodgson as the new national manager yesterday, Redknapp — the bookies’ overwhelming favourite for the job — has had a hard lesson in the unpredictability of football in the last few days.
But it is the hard-to-call results on the field that he is focused on ahead of tonight’s match.
“You can’t predict results,” he told Spurs TV. “Manchester United had an eight-point lead after [Manchester] City got beat at Arsenal, you thought that was the end of them, you thought it was all over. You just can’t tell. You never know. You just have to keep going. That’s all we can do. We have to keep going and if we play well, we can do it.’’