The four-year-old is set to have just her second try at 10 furlongs in the Group One event after finishing second on her first attempt in May.
She subsequently reverted to a mile to finish second in a Curragh Group Three last time, but the longer trip holds few fears for Prendergast.
He said: “She would be my definite runner. I’ve no concerns over the trip. She ran over a mile and two in the Blue Wind at Naas and it was just that the winner (Euphrasia) skipped away.
“She had Dermot Weld’s good mare (Princess Highway) behind her and Rehn’s Nest, who was then placed in the Irish 1,000 Guineas.
“It’ll be a very hot race, although some of the better ones will have raced at Ascot and might not run, but she should run well.
“She likes good ground and hopefully it’ll be good next weekend.”
La Collina has not tasted victory since landing the Group One Phoenix Stakes as a juvenile back in 2011 and Prendergast would love to secure another top-level victory.
He added: “She’s been great for us and solid as a rock. It would be great to get another Group One with her.”
Meanwhile the Gordon Stakes at Goodwood and the Great Voltigeur Stakes at York have emerged as possible summer targets for Telescope.
The Michael Stoute-trained colt was so impressive on his second juvenile appearance at Newmarket he headed into the winter as a leading hope for the Investec Derby, but he has not yet been seen in competitive action as a three-year-old.
A minor setback ruled him out of his intended prep run in the Dante Stakes and after failing to sparkle in a racecourse gallop, a trip to Epsom was ruled out.
Harry Herbert, racing manager for owners Highclere Thoroughbred Racing, is looking forward to seeing the son of Galileo return in the second half of the campaign and also has one eye on next season.
Herbert said: “Michael doesn’t want to be drawn on a set plan, which I understand, but he’s doing very well and he’s doing two strong canters in two days.
“The horse is thriving again but I don’t know when he’ll come out.”