Both Nicky Henderson-trained runners were among the 11 declared for the 3m1f contest, where they will be joined by stablemate Master Of The Hall.
Nacarat is back to defend his title, while Medermit will tackle the furthest trip of his career.
Hunt Ball, who has improved 85lb this season, will carry owner Anthony Knott’s colours in a graded race for the first time.
Big Buck’s will face seven rivals in the BGC Liverpool Hurdle at Aintree tomorrow as he goes in search of an incredible 17th win in a row.
Andy Stewart’s pride and joy won his fourth World Hurdle at Cheltenham.
Nicholls also runs the lightly-raced Poungach and the enigmatic Tidal Bay.
Alan King’s Smad Place, just over eight lengths behind third in the World Hurdle, seems to be the only serious rival for Big Buck’s.
Sabrina Harty’s Won In The Dark is the sole Irish challenger.
Champion Hurdle winner Rock On Ruby will have to be at the top of his game to follow up in what looks an intriguing John Smith’s Aintree Hurdle on Saturday.
Paul Nicholls also runs Zarkandar, who made good late headway at Cheltenham and should be suited by the step up in trip.
Ruby Walsh rode Hurricane Fly for Willie Mullins in the Champion Hurdle, with Noel Fehily on Rock On Ruby and Daryl Jacob on Zarkandar. While Hurricane Fly is not running, his stablemate Thousand Stars is a possible. Oscar Whisky is Nicky Henderson’s sole entry.
Champion Hurdle runner-up Overturn represents Donald McCain, while Colin Tizzard’s Third Intention and Michael Scudamore’s Saphir River complete the seven entries.
Sprinter Sacre will attempt to confirm his brilliance in the John Smith’s Maghull Novices’ Chase at Aintree on Saturday.
Al Ferof, who lost all chance in the Arkle with a mid-race blunder, could take him on again for Paul Nicholls who may also field Toubab.
Australia Day has been entered by Paul Webber, while Menorah, third in the Arkle, could run for Philip Hobbs.
Venetia Williams is poised to step Pepite Rose up in class.
Astracad, Kudo Country, Kumbeshwar and Lancetto complete the entries.