Dublin have made five changes in personnel for Sunday's Allianz NFL Division 1 showdown with Mayo at Castlebar (throw-in 2.30pm).
Stephen Cluxton, Philip McMahon, Ger Brennan, David Henry and Paul Flynn all come into the Metropolitans' side, as they aim to beat Mayo away for the first time in the league since 1992.
Cluxton replaces Michael Savage between the posts as manager Pat Gilroy continues his rotational policy, although Savage did aggravate his hamstring in DCU's recent Sigerson Cup win over UCC.
As a result, former Ipswich Town goalkeeper Shane Supple has come into the panel this week having overcome injury and is listed on the bench.
Rory O'Carroll is ruled out of the Dublin defence due to Under-21 duty against Louth on Saturday, with McMahon coming in at left corner back and Michael Fitzsimons moving to full-back.
James McCarthy, Sean Murray, Dean Rock and Darren Nelson are also ruled out of contention due to their involvement with the Dublin Under-21s.
One further change to the Dublin defence sees Brennan return to action, following his Sigerson Cup stint with NUI Maynooth. Brennan takes over from James Brogan at left half-back.
Meanwhile, Henry and Flynn replace Tiernan Diamond and Blaine Kelly in attack, with Michael Darragh MacAuley named at full-forward.
A number of players were drafted into the squad for training purposes this week, with Gilroy still counting the cost of injuries to a number of players.
Bryan Cullen aggravated a back injury during DCU's Sigerson Cup campaign and has been given a couple of weeks to recover.
Alan Brogan is still in recovery mode following a hand operation and will not be available until later this month, while Barry Cahill played his first club game last Sunday since recovering from an operation, but is not expected to be back to inter-county fitness for a further three weeks.
Meanwhile, Conal Keaney is expected to return in a fortnight following a quad strain injury, with Tomas Quinn set for a longer spell on the sidelines as his metatarsal fracture sees him ruled out for a month.
Darren Daly and Denis Bastick are also on Dublin's injury list. Daly has undergone an operation after severing ankle ligaments and is out for at least eight weeks, while Bastick is recovering from an ankle operation and will not return to training until the end of this month.
There is good news for Eoghan O'Gara, however, as the Templeogue/Synge Street clubman is set to return to training this weekend after missing out in the last few weeks due to a groin strain.
DUBLIN (NFL v Mayo) - Stephen Cluxton; Paul Conlon, Michael Fitzsimons, Philly MacMahon; Paul Griffin (capt), Cian O’Sullivan, Ger Brennan; Eamon Fennell, Ross McConnell; Alan Hubbard, Paul Flynn, Kevin Bonner; David Henry, Michael Darragh MacAuley, Kevin McManamon.
Substitutes: Shane Supple, Conor McCormack, Neill O’Connor, Hugh Gill, Kevin Nolan, Paul Casey, James Brogan, Denis Carrigan, Darren Magee, Colm Murphy, Tiernan Diamond, Bernard Brogan, Dean Kelly, Brendan McManamon, Paddy Andrews