Defender Colm Farrell has been drafted in as the only change to the Wexford team for tomorrow's All-Ireland SHC quarter-final clash with Waterford in Thurles (throw-in 2pm).
Farrell will start at left half-back, taking the place of James Tonks, but there are also a couple of positional switches to the side that lost heavily to Kilkenny in the recent Leinster final.
With Keith Rossiter still absent due to a groin injury, Meyler has moved David 'Doc' O'Connor to full-back and Paul Roche will start at left corner-back behind Farrell.
Rossiter, Ciaran Kenny, John O'Connor and MJ Furlong are all currently on the Models' injury list.
However, forward duo Stephen Nolan and Barry Lambert could see some action at Semple Stadium after recovering from broken thumb and groin injuries respectively.
Both Nolan and Lambert played in Wexford's 1-22 to 1-21 challenge match defeat to Clare in Templemore last Saturday.
Meyler is hopeful that his charges can produce a big performance against the Deise, particularly after they impressed during the first half of the Kilkenny game.
"I'd always be optimistic every time we go out. We try to improve all the time and after the Leinster final, where we played for the first half and five minutes into the second half, we want to take that level up from 40 minutes to 55 or 60," he admitted.
"Some people said to me that they saw some of the best hurling from Wexford in 10 years and that gives us hope and confidence."
Wexford have won three of the five All-Ireland quarter-finals they have played to date, including last year's 3-10 to 1-14 success over Tipperary.
They also beat Waterford by a point in the National League earlier this year.
WEXFORD (SHC v Waterford) - D Fitzhenry; M Travers, D O'Connor, P Roche; M Jacob, D Stamp, C Farrell; E Quigley, D Redmond; PJ Nolan, W Doran, D Lyng; S Doyle, S Banville, R Jacob (capt).