Ballymaloe Country Relish, based in Little Island, is to sponsor the clean-up on the N25 between Little Island and Midleton.
Its founder, Yasmin Hyde, said it was time businesses put back something into their communities and she intended to lead by example.
She is horrified by the level of litter along the main road and the message it sent out to visitors.
“If we have our roads filthy and dirty, does it not give us a sign of how we run the country? People say you judge restaurants by their toilets,” Ms Hyde said.
“As an Irish citizen I find it embarrassing that we have to live with this mess and I am going to do something about it.”
She said such schemes were common in Australia and the US while Cavan County Council was also endorsing them.
Ms Hyde lives close to the main road and is concerned its poor condition doesn’t send out a good message — especially to tourists.
“We have cruise ships coming into Cobh; passengers getting off them on coaches which come up the N25 and they look out at all the litter. I wonder what thoughts they bring home with them,” she said.
Ms Hyde said Ballymaloe Country Relish will employ JB Services to carry out the first clean-up.
“We have the insurance in place and the initial clean-up will cost €2,000. It will cost €10,000 each year to do.”