The horrific accident happened near Macroom, Co Cork, shortly before 7.30 pm.
The driver of the Toyota Landcruiser was named locally as Tim Roche, a single man from Coolacullig, Coachford, Co Cork. Mr Roche, understood to be a 35-year-old welder, was pronounced dead at the scene by a local doctor.
According to the Garda Press Office, the accident claimed the life of the 26th person on Irish roads so far this year.
The accident happened at Roovesmore, 500 yards on the Farran side of Coachford bridge.
Gardaí were quickly on the scene and sealed off the road for a number of hours as fire brigade personnel from Macroom and Ballincollig cleared up the wreckage.
Mr Roche died just a couple of miles from his home and his body was removed to Cork University Hospital where a post- mortem is expected to be carried out later today.
The injured 27-year-old woman driving the other car was taken by ambulance to Cork University Hospital, but her injuries were not life-threatening.
She was driving a Ford Fiesta and gardaí said it was a miracle that she didn’t suffer more serious injuries.
A Garda spokesman appealed to anybody who saw the accident to contact Macroom Garda Station at 026-20595.
Meanwhile, a pedestrian was killed at Oranswell on the Galway-Moycullen road shortly after 9.30 last night.
In Dublin, a 46-year-old man was killed when the car he was driving collided with a pole at 6.15 last evening. He was removed to Tallaght Hospital where he was pronounced dead.