Madonna will be joined by a host of other A-list stars today to raise awareness about Aids.
The singer will talk in Cannes about her new documentary, 'I Am Because We Are', which concerns children orphaned by Aids in Malawi.
Later will see a fundraising event for amfAR, the Foundation for Aids Research, which is dedicated to the support of prevention of infection, treatment education and sound Aids-related public policy.
Madonna will attend the event, which coincides with the Cannes Film Festival.
The guest list also includes Sharon Stone, Mischa Barton, P Diddy, Liz Hurley, Cannes jury president Sean Penn, Christian Slater, Quentin Tarantino, Donatella Versace, Dita Von Teese, Harvey Weinstein, Cliff Richard and hubby Guy Ritchie.
The glitzy event will include a performance by Mary J Blige and a clip of Madonna’s documentary, which was screened last night in Cannes.
The film features interviews with Bill Clinton among others and shows a stark picture of desperate poverty and children orphaned by Aids.
It also highlights how education can help the situation.
Madonna said: “To say that this film is a labour of love is true, but that’s kind of trivial because really what it is, is a journey of a lifetime.”