Liver transplant girl makes history

AN AUSTRALIAN girl spontaneously switched blood groups and adopted her donor’s immune system following a liver transplant in the first known case of its type, doctors treating her said yesterday.

Demi-Lee Brennan, aged nine, was seriously ill with liver failure when she received the transplant, doctors at a top Sydney children’s hospital told Agence France-Press.

Nine months later it was discovered that she had changed blood types and her immune system had switched over to that of the donor after stem cells from the new liver migrated to her bone marrow.

She is now a healthy 15-year-old, Michael Stormon, a hepatologist treating her, said. Dr Stormon said he had given several presentations on the case around the world and had heard of none like it.

“It is extremely unusual — in fact we don’t know of any other instance in which this happened,” said Dr Stormon. “In effect, she had had a bone marrow transplant. The majority of her immune system had also switched over to that of the donor.”

An article on the case was published in Thursday’s edition of the leading US medical journal, The New England Journal of Medicine.

Doctors who treated Demi-Lee say she is now only under treatment as an outpatient and are interested to know if the case could have other applications in transplant surgery, where rejection of donor organs by the recipient’s immune system is a major hurdle.

Dr Stormon said it appeared that Demi-Lee may have been fortunate because a “sequence of serendipitous events”, including a post-transplantation infection, may have given the stem cells from her donor’s liver the chance to proliferate.

The task now was to establish whether the same sort of outcome could be replicated in other transplant patients, he said.