Osbournes have had enough of reality TV
Sharon, who is suffering from colon cancer, also revealed how her illness had prompted her rock star husband to start drinking again.
A second series of The Osbournes the first is currently being shown in Ireland on Network 2 begins on MTV in the US on November 26.
"This is definitely the last year," Osbourne said in an interview on ABC's 20/20 programme to be screened today. "We can't do it anymore."
The first series drew record ratings for MTV and made former Black Sabbath frontman Ozzy and his family household names in America.
Sharon said the show has "changed us all so much".
Her teenage children Jack and Kelly now have lawyers and business managers.
"Because it's a moment in time, when we were innocent to it all, we went in feet first and you can't recreate that," she said.
"Yes, now, this series, people will see what the first series has done to our lives and it will take people to the next stage. But after that, it's over."
The family hasn't exactly shunned the spotlight.
ABC said yesterday that Ozzy, Sharon and Kelly and Jack will be hosts of the American Music Awards on January 13.
Sharon said Birmingham-born Ozzy had begun drinking again in response to her cancer.
"We agreed to do the show and so the cameras are here all the time," she said.
"So it's a little bit invasive right now and we have no privacy.
"You know when you're sick, you want to be on your own. I can't throw up on my own and Ozzy can't get drunk on his own."
The couple's eldest daughter Aimee does not appear in the show but told ABC interviewer Barbara Walters that she worries about what will happen to her father if anything should happen to Sharon.
"I don't think he even wants to know what life will be like without her," Aimee said.
"And I don't think he would last more than a year without her."
