Manchester United manager Alex Ferguson rang the changes for this crucial Champions League match against Lyon at Old Trafford.
Even though his side triumphed 3-0 at Fulham on Saturday, he decided to shuffle his pack in dramatic fashion.
Ferguson made no less than six changes with the game locked at 1-1 after the first leg and a place in the quarter-finals at stake.
Cristiano Ronaldo, Wayne Rooney, Nemanja Vidic, Anderson, Michael Carrick and Darren Fletcher all returned to the starting line-up.
Argentina striker Carlos Tevez, who scored a late equaliser in the first leg, had to settle for a place on the bench.
Man Utd: Van der Sar, Brown, Ferdinand, Vidic, Evra, Fletcher, Carrick, Anderson, Ronaldo, Rooney, Nani.
Subs: Kuszczak, Hargreaves, Saha, Park, Scholes, O’Shea, Tevez.
Lyon: Coupet, Clerc, Squillaci, Cris, Grosso, Ben Arfa, Juninho, Toulalan, Kallstrom, Govou, Benzema.
Subs: Vercoutre, Bodmer, Fred, Delgado, Keita, Mounier, Boumsong.
Referee: Roberto Rosetti (Italy)