The Germany international has not featured for City since his £37.5m (€44.3m) summer move from Schalke after suffering a hamstring injury in pre-season.
The 20-year-old, who returned to training before the recent international break, said: “I feel good now and I’m ready to play. I’ve trained well and my hamstring is fine so I’m looking forward to finally getting started.”
An appearance in the eagerly-anticipated fixture at Old Trafford could prove a baptism of fire. The match has been heavily hyped, with both clubs having recruited significantly over the summer and having started their Premier League campaigns well.
A fierce atmosphere is anticipated and the game will also see Jose Mourinho and Pep Guardiola, new managers at United and City respectively, go head to head in an intriguing renewal of an old rivalry.
Sane said: “I’ve played in derby games in Germany but this should be a great match and one I’m really looking forward to, especially because Pep Guardiola is taking on Jose Mourinho.
“It should be a special game and we can sense the expectation all around the city from our supporters.
“It’s going to be exciting and I hope I can play some part and help us bring back three points.”
Sane’s debut could come alongside that of his fellow German Ilkay Gundogan, another summer signing who is yet to play because of injury. Defender Bacary Sagna is also back in contention and captain Vincent Kompany could return too.
Sane’s availability could facilitate a reshuffling of the forward line in the absence of suspended striker Sergio Aguero.
If Guardiola decides not to use Kelechi Iheanacho as an out-and-out replacement for the Argentinian, he could move Nolito, Kevin De Bruyne or Raheem Sterling into a move advanced role.
Meanwhile, Adnan Januzaj is determined to prove his critics wrong as he attempts to revive his career at Sunderland after discovering he was not in Jose Mourinho’s short-term plans.
The 21-year-old Belgium international was allowed to leave United for the Stadium of Light on a season-long loan deal during the summer with some questioning his apparent lack of progress since he burst on to the Premier League scene as a precocious teenager.
Januzaj said: “It is not to re-establish myself, it is just to prove to some of the people that they were wrong. I will work hard to show they were wrong over the past few years.
“Part of my mentality is to never give up. Even if something goes a bit wrong, you always have to keep working — that is what I have been doing. Now I have the chance to prove myself again.”
Januzaj, who spent the first half of last season on loan at Borussia Dortmund, was handed his senior debut for United by then manager David Moyes at the start of the 2013-14 season, and the midfielder admitted he jumped at the chance of a reunion on Wearside.
He said: “I spoke with the manager and he asked me if I wanted to come here. I said that I wanted to play football. He gave me the opportunity to do that and I am really thankful for that.
“He is building a very good team here. It is still early for him to show people what he can do, he needs time to adapt to the club, of course. But I think he is doing very, very well and all of the players that have been signed are all very good players.”
Elsewhere, Paris St Germain boss Unai Emery has insisted Blaise Matuidi is happy at the Parc des Princes.
The France international midfielder was the subject of reported interest from Juventus and United during the transfer window but PSG did not want to sell.
Emery said: “He is happy at Paris St Germain. He is red and blue. On Wednesday, he had a good training session. He is ready physically and mentally. “