After beating Hajduk Split in Croatia in their first game on August 4, and coming through a group containing Besiktas, Dynamo Kiev and Maccabi Tel Aviv, Stoke found Champions League regulars Valencia a step too far.
Defeat at home last week left the Potters with a mountain to climb and they might have managed it had Kenwyne Jones taken one of two glorious opportunities, but he fluffed his lines and Jonas’ 24th-minute goal earned Los Che a 1-0 win on the night and a 2-0 win on aggregate.
Pulis said of the run: “It’s been fantastic, we’ve really enjoyed it. It’s given everybody at the club a lift. It’s something we’ve never experienced before.
“Tonight we had a right go. In the first 20 minutes, if we’d just have had a bit of luck, and it just didn’t come.”
Elsewhere last night Eredivisie leaders PSV Eindhoven blazed into the last 16 of the Europa League by wrapping up a 4-1 win on the night and a 6-2 aggregate victory over Trabzonspor.
Udinese hammered PAOK Salonika 3-0 in Greece, putting them through after a 0-0 draw in the first leg.
Former Manchester United striker Mame Biram Diouf scored the only goal as Hannover beat Club Brugge 1-0 to complete a 3-1 aggregate win.
Nacer Chadli’s 29th-minute effort earned FC Twente a 1-0 win over Steaua Bucharest for a 2-0 aggregate victory, while a goalless draw was good enough for Standard Liege to squeeze past Wisla Krakow 1-1 on away goals.
Athletic Bilbao beat Lokomotiv Moscow 1-0 to also advance on away goals on a 2-2 aggregate. Iker Muniain scored the crucial goal two minutes after Fernando Amorebieta saw red on 60 minutes. Bilbao face Manchester United in the next round.
Last year’s runners-up Braga were knocked out despite beating Besiktas 1-0 in Turkey on the night, losing out 2-1 on aggregate.
Atletico Madrid eased home against Lazio with a 1-0 win on the night giving them a 4-1 aggregate success.
Ukrainians Metalist Kharkiv completed an emphatic 8-1 aggregate win over Salzburg with a 4-1 win in Kharkiv, while Greek side Olympiacos rounded off a 2-0 aggregate win over Rubin Kazan with a 1-0 second leg win. Matias Fernandez scored a late winner for Sporting Lisbon against Legia Warsaw, which was enough to see the Portuguese side 3-2 on aggregate after a 1-0 win on the night.
Schalke triumphed over Viktoria Plzen in the only match to go extra-time, with Klaas-Jan Huntelaar completing his hat-trick in extra-time to put the Germans through.