Mirko Vucinic put the Bianconeri in front in the 12th minute but Maicon levelled for the hosts in the 16 minutes later.
Claudio Marchisio restored Juve’s advantage in the 33rd minute and he was also unlucky not to earn a penalty just before half time.
Inter were unable to find a way back into the game and succumbed to their fifth defeat in nine games.
In-form AC Milan inflicted a 3-2 home defeat on Roma to stay in touch with Juve.
Zlatan Ibrahimovic put the visitors ahead in the 17th minute before Nicolas Burdisso equalised shortly after.
Alessandro Nesta restored Milan’s lead on the half-hour mark and Ibrahimovic gave the visitors a two-goal cushion with his second goal of the game in the 78th minute.
Roma substitute Bojan reduced the arrears three minutes from time but Milan held on for their fourth straight league victory.
Catania moved level on points with fifth-placed Napoli with a 2-1 win at the Stadio Massimino.
Edinson Cavani put Napoli ahead in the first minute but the Sicilians turned the game around with goals from Gonzalo Bergessio and Giovanni Marchese.
To add insult to injury, Napoli ended the game with 10 men after Mario Santana was controversially sent off late in the first half for a second bookable offence.
In Spain, Lionel Messi scored a first-half hat-trick as Barcelona thrashed Real Mallorca 5-0, while Real Madrid provisionally moved to the top of the Primera Division standings after in-form Gonzalo Higuain fired them to victory over Real Sociedad.
Messi netted three times in 18 minutes — the Argentinian’s third league hat-trick of the campaign — before Isaac Cuenca added a fourth goal in the second half with his first senior strike and Dani Alves rounded off the scoring with a brilliant late goal.
Barca’s victory was their third 5-0 triumph in six league games at the Nou Camp this season while they have also won 8-0 against Osasuna.
The win was also Barca’s eighth consecutive clean sheet in all competitions.
It was not enough to leave Pep Guardiola’s men top though, Madrid taking that honour thanks to Higuain’s solitary first-half goal against Real Sociedad at the Anoeta.
Higuain, an international compatriot of Messi’s, has now struck 11 times in his last eight games for club and country.
Villarreal moved out of the relegation zone and eased the pressure on coach Juan Carlos Garrido with a much-needed 2-0 win over Rayo Vallecano.
Sofiane Feghouli scored his first two goals of the season to help Valencia to a routine 3-1 home win over Getafe, while Osasuna ended early surprise leaders Levante’s seven-match winning run with a deserved 2-0 victory to maintain their own unbeaten home run.