Casey to make first Six Nations start as Farrell makes six changes for Italian job 

As expected, Ross Byrne starts in place of the injured Johnny Sexton. 

READY TO GO: Ireland's Craig Casey. Pic:: Brian Lawless/PA Wire.

Craig Casey will make his first Guinness Six Nations start after Andy Farrell made six changes for Ireland’s round-three clash against Italy in Rome on Saturday.

Scrum-half Casey replaces Munster rival Conor Murray, who started the first two games of the championship in the absence of injured first-choice number nine Jamison Gibson-Park with the Test centurion moving to the replacements bench at Stadio Olimpico.