The Guinness PRO12 table-toppers have re-jigged their back-line with scrum-half Paul Marshall getting a rare start. Charles Piutau moves to full-back with Jared Payne joining Darren Cave in midfield.
Up front, Ireland captain Rory Best gets his first start of the season while Kyle McCall wears the number one jersey. Ireland star Tommy Bowe is likely to get his first run-out for five months having been named on a very strong replacement bench.
Meanwhile, Ireland’s midfield general Payne admits there is room for improvement despite their good form this season. “We are doing some good things but some poor things too.
“I don’t know if it is the most talented Ulster team I have played with but it is definitely the most honest; they are really good at addressing what has gone wrong regardless of the result.
“Everyone is keen to get better,” said Payne who recently became a father. He laughed: “I’m just concentrating on being awake on time every morning to get into Ulster. I have to get my act together or else I’ll be sitting on the bench.”
Ospreys, meanwhile, make six changes from the team well beaten by Leinster with Dan Evans returning at full-back. Up front Bradley Davies joins Wales second-row partner Alun Wyn, Dan Baker replaces Tyler Ardron at number eight and loose-head prop Nicky Smith makes his 50th appearance for the Welsh region replacing Paul James in the front row.
C Piutau, C Gilroy, J Payne, D Cave, L Ludik, P Jackson, P Marshall; : K McCall, R Best, R Ah You, A O’Connor, F van der Merwe (capt), I Henderson, S Reidy, R Wilson.
J Andrew, C Black, R Kane, K Treadwell, R Diack, R Pienaar, B Herron, T Bowe.
D Evans, J Hassler, B John, J Matavesi, E Walker, D Biggar, R Webb; N Smith, S Parry, D Arhip, B Davies, A Wyn Jones (capt), J King, J Tipuric, D Baker.
S Baldwin, P James, M Fia, R Thornton, O Cracknell, T Ardron, T Habberfield.
Ben Whitehouse (WRU)