Cork Constitution (third) are away to champions Lansdowne and will be conscious they must win to keep ahead of fourth-placed UCD.
The Students are at home to Ballynahinch and look good to take five points.
At the other end of the table, Galwegians take on Terenure and the winners of that could well go on to avoid a relegation play-off ordeal.
On the last weekend of action in the lower divisions there will be a lot of sweat lost in the build up to the play-off semi-finals and in the battle for automatic promotion.
Old Crescent have already clinched the Division 2C title and they will be joined in Division 2B by Rainey Old Boys, Tullamore, Bruff or Wanderers, all of whom are confirmed participants in the play-off games.
There is even more to play for in Division 2A with this final round of games of crucial importance for five teams.
Naas top the table by three points from Banbridge, while UCC are six points adrift and four ahead of both Nenagh Ormond and Cashel.
College take on Nenagh at the Mardyke today (2.30pm) and a losing bonus point will cement their place in the last four.
However, coach David O’Mahony is conscious of Nenagh’s strengths and says: “Our total focus is this weekend, we’re not looking to the possibility of a semi-final because we need to negotiate this one first.
“It’s very tight, a couple of weeks ago it looked like Banbridge would run away with it and they seem to have done a City of Derry (in Division 2B) on it, they’ve lost a few league games and have fallen back to the point Naas will probably get automatic promotion now.
“You would expect Banbridge to have enough to get one of the four spots and it will come down to two spots being available between us, Nenagh and Cashel. We’re four points ahead and Nenagh would have to get a bonus point because our points difference is so much better.”
Meanwhile, two more Cork teams are heavily involved in the business end of the Division 2B campaign, with both Highfield (home to Bective) and Sunday’s Well (away to Greystones) hoping Derry have another slip-up at home to Barnhall.
It’s possible one of the two who produced a magnificent local derby game last week could be crowned champions later today but you wouldn’t bet too heavily on Derry losing a sixth game in succession either.