Now that successive trips to Paris and Edinburgh have been negotiated, the next two rounds will unfold amid the reassuring surroundings of their London stronghold.
First up are unbeaten Ireland, who issued a clear statement of intent in crushing Wales 26-3, before Warren Gatland’s champions arrive a fortnight later.
Having lost narrowly to France and routing Scotland 20-0 on Saturday, there is no margin for error if England are to remain in title contention.
Lancaster has braced Twickenham for a Six Nations classic against the Irish and hopes to reward home fans with a decisive victory.
“Playing the next two games at home is massive for us. We’ve trained at Twickenham more now recently which has helped,” Lancaster said.
“The way the crowd has got behind us in the last few games has been huge, certainly in the autumn internationals.
“We owe them a decent performance because they’re definitely backing us.
England would still be chasing the Grand Slam themselves had their defence not been outwitted by Gael Fickou’s late try in Paris, but comfort has since been drawn from the efficiency displayed at Murrayfield.
More tries should have been added to the two scored by Luther Burrell and Mike Brown, but it was otherwise an accomplished display that was hard to fault.
“Overall we made a statement in this game, yes. In parts we played really well in very difficult conditions,” said Lancaster, in reference to the mudbath of a pitch at Murrayfield.
“I actually thought we made a statement against France last weekend and we were disappointed not to have won. I’m pleased that we’ve had a good win and that can take us into two massive home games.”
If England’s three-quarter line continue to perform well, Lancaster will face a selection conundrum when Manu Tuilagi recovers from his chest injury.
Burrell and Billy Twelvetrees have formed a promising centre partnership and it would be harsh to dislodge either Jack Nowell or Jonny May from the wings to accommodate Tuilagi’s return.
“I suspect that Manu might run out of time for this Six Nations,” Lancaster said.
“I’m not saying he will, but the reality is if he doesn’t return until the start of March, he’s going to run out of time. We’ll wait and see.”
SCOTLAND: S Hogg, T Seymour, A Dunbar, M Scott, S Lamont, D Weir, G Laidlaw; R Grant, R Ford, M Low, T Swinson, J Hamilton, R Wilson, C Fusaro, DDenton.
Replacements: M Evans for Seymour (64), D Taylor for Scott (72), C Cusiter for Laidlaw (64), A Dickinson for Grant (42), S Lawson for Ford (42), G Cross for M Low (67), J Gray for Hamilton (69), J Beattie for Denton (52).
ENGLAND: M Brown, J Nowell, L Burrell, B Twelvetrees, J May, O Farrell, D Care; J Marler, D Hartley, D Cole, J Launchbury, C Lawes, T Wood, C Robshaw, B Vunipola.
Replacements: A Goode for May (70), L Dickson for Care (73), M Vunipola for Marler (64), T Youngs for Hartley (69), H Thomas for Cole (75), D Attwood for Launchbury (62), B Morgan for B Vunipola.
Referee: Jerome Garces (France).