Henderson, who is limbering up for his day job as a National Hunt trainer, has already taken this prestigious staying handicap on two occasions through dual-purpose performers Landing Light (2003) and Caracciola (2008).
Eddie Ahern was aboard the latter and he has been chosen for potential favourite Veiled, a winner at the course in May as well as on her most recent start in the Ascot Stakes.
Old-timer Sentry Duty, who was sixth last year, is the mount of Johnny Murtagh.
“Things didn’t go according to plan last year (for Sentry Duty) but he finished his race really well and not surprisingly this has always been the plan,” said Henderson.
“He unfortunately got caught up in a horrible melee at Goodwood but Kieren (Fallon) came back very positive.
“Stall one sounds good but you have to hold your position, which I’d hope Sentry Duty will be able to do as he’s not a slow horse.
“He wants fast ground so that will be lovely. I’d hoped Kieren would be able to ride him but he’s got to ride one for Luca (Cumani), so Johnny Murtagh seemed a good substitute to me.
“Veiled has had a bit of a break since Ascot as she’d been on the go all winter.
“I think the ground is all right for her – although you wouldn’t mind a drop of rain.
“Obviously she does stay very well and over two and a quarter miles at Newmarket you have got to stay. ”That is her strength.”
Another predominately jumping trainer David Pipe saw his father, Martin, strike in the Cesarewitch on several occasions in the not too distant past and his Pond House stables have three representatives.
Big Occasion was a winner for Aidan O’Brien last year, while Beyond appears the leading hope after making a winning debut for the stable at Sandown in July.