Ryan Moore rode the Galileo filly at the Curragh for the first time and will be back on board again.
She looked to have the Irish Classic in the bag before being swamped close home by stablemate Misty For Me.
“When she gets to the front she doesn’t do much,” said O’Brien.
“For a Galileo she has loads of speed, she gets a mile well but doesn’t want to be in front too long.
“Ascot is a tough enough finish, but the Curragh is a long way up and when you start your run you have to keep going.”
Jim Bolger won the race in 2008 with Lush Lashes and runs Claiomh Solais in this year's renewal.
“Her full sister (Gile Na Greine) was second in the Coronation last year,” said Bolger.
“She ran a very good race in the Irish Guineas, she wasn’t beaten far (two lengths) and she’s an improver so we’ll be expecting her to run well.
“She wouldn’t want the ground too soft.
“In two months time I’d say she’ll be right up there, but she’s already knocking on the door.”
Martin Dwyer is looking forward to the ride on Theyskens’ Theory.
Derby-winning jockey Dwyer has partnered the Bernadini filly in all but two of her seven starts to date and his absence in the Fillies’ Mile and Breeders’ Cup can be explained through injury.
He was back on board the Brian Meehan-trained three-year-old when she made her seasonal reappearance in a Listed race at York, and was impressed by the way she was able to concede weight to all of her rivals in winning by upwards of three and a quarter lengths.
“I’m really looking forward to riding her, she’s a lovely filly,” said Dwyer.
“She was a very good two-year-old last year and then she started to grow, which meant towards the end of last year she got really tall and gangly and went through a growth spurt.
“She’s made up into a nice three-year-old, she had a nice easy race at York when she won the Listed race.
“She’s improved massively and I think she’s got a great chance,” he told At The Races.
Richard Hannon’s Memory was well fancied for the 1000 Guineas but blotted her copybook by refusing to leave the stalls, and that is not the first time she has shown signs of trouble in the gates.
The champion trainer has given her plenty of practice in the meantime and his new worry is the forecast rain.
“Every drop of rain that falls will lessen Memory’s chance. She is such a great mover with a turbo-charged finish, but if the ground turns soft it could blunt her speed,” said Hannon.
“Hughesie (Richard Hughes) wants to get Memory covered up and though we don’t have the best draw (9), he still has four fillies outside him, including the favourite, Together.
“Hopefully she can be buried in the pack and produce the same sort of finishing kick that enabled her to win the Albany last year.”
John Gosden has two solid chances with 1000 Guineas third Maqaasid and Musidora winner Joviality.
“Maqaasid ran a great race in the 1000 Guineas, where the strong headwind at Newmarket just sapped her stamina close home,” said Gosden.
“She’s got a lot of class and going round a bend should help her to stay the mile.
“Joviality is bred to be a miler and the extra two furlongs of the Musidora was as far as she wants to go.
“She’s very tough and I’m glad we sat out the French Oaks as it was a hot renewal. This looks a much more open race.”