Paddy Colfer and Rory Stafford will make their first starts of the season when Wexford clash with Meath in Sunday's Leinster SFC quarter-final at Dr Cullen Park (throw-in 3.30pm).
Stafford, who was used as a substitute in last month's NFL Division 3 final win over Fermanagh, will partner Eric Bradley in Wexford's midfield.
Colfer struck 1-1 off the bench in the Fermanagh game and having recovered from a slight injury, the Clongeen clubman comes in at full-forward for Wexford's championship opener.
In all, Wexford boss Jason Ryan has made three changes to the side that started the Division 3 decider - Colfer, Stafford and wing back Nicky O'Sullivan are the new inclusions.
Anthony Masterson remains in goal, taking over the mantle from the retired John Cooper.
Although Meath have already had a championship outing - a very comfortable win over Carlow at Croke Park - Wexford's 2004 All-Star forward Mattie Forde is confident of a good showing from his side this weekend.
"Five or six years ago Wexford would have been 90% beaten before they went on the pitch against a Meath or an Offaly or a Dublin," Forde said.
"I think there has been a shift in attitudes. We have beaten Meath the last four times we have played them in league and championship."
Sunday's game will be the sixth Leinster championship clash between the counties in the last 45 years and only the third since 1981.
Wexford, for whom Forde scored 0-12, ran out 1-19 to 1-13 winners in the last clash two years ago.
In his first season at the helm, Ryan helped Wexford win six and draw two of their eight National Football League games, which gave them the distinction of being the only unbeaten team in this year's league.
WEXFORD (SFC v Meath): A Masterson; C Morris (capt), P Wallace, B Malone; N O'Sullivan, D Murphy, N Murphy; R Stafford, E Bradley; PJ Banville, R Barry, A Flynn; C Lyng, P Colfer, M Forde.