Clare team captain Michael O'Shea has lost his race to be fit for the Banner's Munster SFC quarter-final clash with Waterford on Sunday at Cusack Park (throw-in 3.30pm).
A calf injury has gotten the better of O'Shea and the St. Senan's Kilkee clubman will sit out the Ennis encounter.
O'Shea's absence means full-back Conor Whelan from Doonbeg will skipper a Clare team that shows six changes in personnel to the side that lost to Waterford in last year's championship.
There are two championship debutants in Cratloe teenager Sean Collins, who has been pencilled in at centre-forward, and the 20-year-old David Tubridy from Doonbeg, who will start at corner forward.
Niall Considine, Darragh Kelly, Ger Quinlan and Alan Clohessy are the four other players who missed the 2007 defeat to the Deise in Dungarvan.
Both Considine and Kelly have recovered from injuries to start, while goalkeeper Joe Hayes is fit to start despite missing Tuesday night's training session.
CLARE (SFC v Waterford): J Hayes; D Conole, C Whelan (capt), G Kelly; N Considine, D Kelly, J Hayes; G Quinlan, G Brennan; D Russell, S Collins, A Clohessy; R Donnelly, S Hickey, D Tubridy.