Brendan Egan and John McPartland have been drafted into the Sligo side for Sunday's Connacht SFC final against Galway (Dr. Hyde Park, throw-in 2pm).
Egan will lead the Yeats men's attack from centre-forward, while McPartland, who kicked a point as a substitute in last month's semi-final win over Roscommon, gains a starting berth at left corner forward.
Philip Gallagher and Adrian Marren are the players to make way.
Sligo manager Tommy Breheny has also made a considerable positional switch with his younger brother Mark, who was centre-forward last time out, now listed at full-forward.
Mark Breheny, the 26-year-old St. Mary's clubman, has become the attacking fulcrum of Sligo, chipping in with some crucial frees and taking on the role of playmaker. He is currently the Connacht championship's joint-top scorer with 0-10 in two games.
Injury has ruled the Taylor brothers, Tony and Paul, and Dara McGarty out of the contention for what is Sligo's first appearance in a Connacht final since 2002.
While Sligo last won the Nestor Cup back in 1975, Sligo boss Tommy Breheny reckons his players have it within them to end the county's long wait for provincial success.
"For these players it is a huge motivation to be in a Connacht final - they are 70 minutes away from winning a title and are up against one of the best teams in the country.
"Given the age profile of the squad, this is a once in a lifetime opportunity for some of the players. For others, it will be their first time to make an impact on the biggest stage in the province," Breheny said.
Sligo's last appearance in the Connacht decider, five years ago, saw them lose to Galway by three points. They also met Galway in last year's Connacht championship, losing a quarter-final tie by 0-19 to 1-12.
SLIGO (SFC v Galway) - P Greene; C Harrison, N McGuire (capt), R Donovan; P McGovern, M McNamara, J Davey; K Quinn, E O'Hara; B Curran, B Egan, S Davey; D Kelly, M Breheny, J McPartland.