Pascal McConnell will make his first appearance of the 2009 Championship when All-Ireland champions Tyrone take on Kildare at Croke Park on Sunday (throw-in 4pm).
McConnell, who returned last month from a six-month lay-off due to a dislocated kneecap, will take over the goalkeeping duties from the injured John Devine.
Devine was ever-present during the Red Hands' Ulster title-winning run, but dislocated his shoulder in training last Sunday and Tyrone manager Mickey Harte says he will be out for at least two months.
That is the one enforced change Harte has made to the side that beat Antrim by 1-18 to 0-15 in the Ulster final two weeks ago.
All-Star midfielder Enda McGinley is on the substitutes bench once again, as Kevin Hughes and Sean Cavanagh maintain their centre-field partnership.
Forwards Martin Penrose and Stephen O'Neill failed to score against Antrim but keep their starting places, with Ryan Mellon and Niall Gormley still fighting off hamstring problems.
Having been named amongst the substitutes, Mellon could have some involvement in his county's seventh All-Ireland quarter-final in nine years.
Tyrone drew 0-07 to 1-04 in their last competitive clash with Kildare in the 2008 National League in Omagh.
TYRONE (SFC v Kildare) - P McConnell; PJ Quinn, Justin McMahon, R McMenamin; D Harte, C Gormley, P Jordan; K Hughes, S Cavanagh; B Dooher (capt), T McGuigan, Joe McMahon; M Penrose, S O'Neill, O Mulligan.